[{"data":1,"prerenderedAt":394},["ShallowReactive",2],{"slug-whats-happening-in-your-stomach-gastric-alimetry-review":3},{"post":4,"relatedPosts":166,"relatedBooks":297},{"id":5,"date":6,"date_gmt":7,"guid":8,"modified":10,"modified_gmt":11,"slug":12,"status":13,"type":14,"link":15,"title":16,"content":18,"excerpt":21,"author":23,"featured_media":24,"comment_status":25,"ping_status":25,"sticky":26,"template":27,"format":28,"meta":29,"categories":30,"tags":32,"project_category":40,"contact_email_category":41,"yst_prominent_words":42,"class_list":48,"better_featured_image":63,"acf":100,"yoast_meta":110,"_links":113},48309,"2022-12-08T10:00:00","2022-12-08T09:00:00",{"rendered":9},"https:\u002F\u002Fmedicalfuturist.com\u002F?post_id=48309&_wpnonce=8fb2ad724e&status=auto-draft&type=post","2022-12-07T16:06:46","2022-12-07T15:06:46","whats-happening-in-your-stomach-gastric-alimetry-review","publish","post","https:\u002F\u002Fmedicalfuturist.com\u002Fwhats-happening-in-your-stomach-gastric-alimetry-review",{"rendered":17},"What’s Happening In Your Stomach? – Gastric Alimetry Review",{"rendered":19,"protected":20},"\n\u003Cp>I’ve been wanting to test the gastric sensor by \u003Ca rel=\"noreferrer noopener\" href=\"https:\u002F\u002Fwww.alimetry.com\u002F\" target=\"_blank\">Alimetry\u003C\u002Fa> for a while now. This is a unique product, I’ve never seen anything similar before, and – if it lives up to its promises – it offers valuable data in a health segment where data is scarce. \u003C\u002Fp>\n\n\n\n\u003Cp>There is a huge demand for a better understanding of the workings of our gastric systems, and so far nobody has been able to meaningfully collect digital health data about it. Although the stomach is controlled by an electrical conduction system regulating its contractions, the signals are weak, a hundred times weaker than those of the heart.\u003C\u002Fp>\n\n\n\n\u003Cp>The technical challenge so far was to find a way to capture these mild signals in a clinically reliable way. A reliable solution that could either be used by patients at home or at the point of care would be a hit. This is a niche segment, but one with significant demand. \u003C\u002Fp>\n\n\n\n\u003Cfigure class=\"wp-block-image size-large is-style-default\">\u003Cimg loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"513\" src=\"https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F12\u002FZOA4824-768x513.jpg\" alt=\"Gastric Alimetry Body Surface Gastric Sensor tmf\" class=\"wp-image-48319\" srcset=\"https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F12\u002FZOA4824-768x513.jpg 768w, https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F12\u002FZOA4824-1536x1026.jpg 1536w, https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F12\u002FZOA4824.jpg 1617w\" sizes=\"auto, (max-width: 768px) 100vw, 768px\" \u002F>\u003C\u002Ffigure>\n\n\n\n\u003Cp>Properly diagnosing gastric dysfunctions is notoriously tricky: most of the data comes from observations. Patients eat something and they and their practitioners try to figure out what happens and what is the reason if something happens. It involved lots and lots of guesswork, and too often multiple rounds of incorrect theories on the causes of various symptoms.\u003C\u002Fp>\n\n\n\n\u003Cp>Thus I was intrigued to lay my hands on a set of gastric sensors and observe it in action. Let’s see what I learned. As our test involved one willing team member of The Medical Futurist, the review will also include the patient’s point of view in the later sections.\u003C\u002Fp>\n\n\n\n\u003Ch3 class=\"wp-block-heading\">What is in the ‘Body Surface Gastric Mapping System’ package?\u003C\u002Fh3>\n\n\n\n\u003Cp>The delivered package included the following parts:\u003C\u002Fp>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>A charger dock – with 4 different adapters for all kinds of global outlets, making the device universally usable. The dock needs to be plugged in to charge the reader\u003C\u002Fli>\n\n\n\n\u003Cli>A reader with Bluetooth connectivity and wireless charging capability, you only need to place it on the dock, no wires are needed here. One confusing thing: once you paired your reader with the tablet, it stops showing battery charging levels, even if you disconnect them. The tricky part is that the app also keeps showing the battery charge level it had when it was paired, so you need to unpair and pair them again if you want to see the actual figure while charging  \u003C\u002Fli>\n\n\n\n\u003Cli>Two packages of disposable arrays and array templates, each pair separately sealed\u003C\u002Fli>\n\n\n\n\u003Cli>An iPad mini preinstalled with the Alimetry app – and locked to its exclusive use\u003C\u002Fli>\n\n\n\n\u003Cli>A user manual booklet with very detailed information on the device, its parts, the setup and the whole process\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Ch3 class=\"wp-block-heading\">Ease of use\u003C\u002Fh3>\n\n\n\n\u003Cp>As a first-time user, I need to offer kudos to the user-experience team. Although the whole process seems fairly complex, it was very straightforward. I started by reading the full user manual before charging and turning on the other devices, but to be honest, all would be equally obvious just by launching the app and following its step-by-step setup instructions. \u003C\u002Fp>\n\n\n\n\u003Cp>The app breaks down the test into small steps, not allowing the practitioner to move forward until everything is in line with the requirements. For example, it is not possible to start setting up the test unless the reader is sufficiently charged to safely last for the entire 4.5 hours of a full cycle.\u003C\u002Fp>\n\n\n\n\u003Cfigure class=\"wp-block-image size-large is-style-default\">\u003Cimg loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"513\" src=\"https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F12\u002FZOA4852-768x513.jpg\" alt=\"Gastric Alimetry Body Surface Gastric Sensor tmf\" class=\"wp-image-48315\" srcset=\"https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F12\u002FZOA4852-768x513.jpg 768w, https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F12\u002FZOA4852-1536x1026.jpg 1536w, https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F12\u002FZOA4852.jpg 1617w\" sizes=\"auto, (max-width: 768px) 100vw, 768px\" \u002F>\u003C\u002Ffigure>\n\n\n\n\u003Cp>The only reason you should not rely on the app alone is that the user’s manual includes crucial information on how the patient should prepare for the test, and these are not included in the app. \u003C\u002Fp>\n\n\n\n\u003Ch3 class=\"wp-block-heading\">The 4.5-hour test cycle\u003C\u002Fh3>\n\n\n\n\u003Cp>Active participation from the physician is mainly required at the setup phase of the Gastric Alimetry process. \u003C\u002Fp>\n\n\n\n\u003Cp>\u003Cstrong>You need to complete the following steps in advance:\u003C\u002Fstrong>\u003C\u002Fp>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Charge the reader to at least 83%\u003C\u002Fli>\n\n\n\n\u003Cli>Set up the iPad by connecting it to a stable Wi-Fi network, setting up a passcode and enabling guided mode and setting up a passcode for that one as well. Guided mode is required so the iPad will not turn off during the test, nor can patients accidentally quit the app\u003C\u002Fli>\n\n\n\n\u003Cli>Charge the tablet to at least 60%\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cp>\u003Cstrong>Just before the test:\u003C\u002Fstrong>\u003C\u002Fp>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Patient measurements prior to the test: to allow proper positioning of the array, you need to measure Xiphoid-Umbilicus and Xiphoid-ASIS distances as well as waist circumference, these values will need to be entered in the app during the preparation phase\u003C\u002Fli>\n\n\n\n\u003Cli>Prepare the skin with a prep gel\u003C\u002Fli>\n\n\n\n\u003Cli>Mark the proper array position on the skin using the array template – you will be guided based on the previous measurements by the app\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cp>\u003Cstrong>And at the start of the test:\u003C\u002Fstrong>\u003C\u002Fp>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Connect the disposable array to the reader and secure it by closing the reader lids\u003C\u002Fli>\n\n\n\n\u003Cli>Remove the adhesive covers from the array and position the reader and array on the patient’s body\u003C\u002Fli>\n\n\n\n\u003Cli>Measure the distance between the bottom of the array and the Umbilicus and enter this value into the app (negative values for small frames, when the array ends below the belly button)\u003C\u002Fli>\n\n\n\n\u003Cli>Let the app check signal strength\u003C\u002Fli>\n\n\n\n\u003Cli>Enter guided mode and hand the tablet to the patient, so they can record any symptoms in the following hours. At this stage, I needed to force-restart the tablet to launch guided mode (and thus enter all the data again), which, as I researched, is a well-known problem of iPad minis\u003C\u002Fli>\n\n\n\n\u003Cli>And finally, make sure that the patient will remain in a comfortable reclining position for the next 4.5 hours – comfort brakes are allowed if necessary\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cfigure class=\"wp-block-image size-large is-style-default\">\u003Cimg loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"513\" src=\"https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F12\u002FZOA4836-768x513.jpg\" alt=\"Gastric Alimetry Body Surface Gastric Sensor tmf\" class=\"wp-image-48317\" srcset=\"https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F12\u002FZOA4836-768x513.jpg 768w, https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F12\u002FZOA4836-1536x1026.jpg 1536w, https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F12\u002FZOA4836.jpg 1617w\" sizes=\"auto, (max-width: 768px) 100vw, 768px\" \u002F>\u003C\u002Ffigure>\n\n\n\n\u003Cp>\u003Cstrong>During the test:\u003C\u002Fstrong>\u003C\u002Fp>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>After the first 30 minutes the patient needs to consume a “standard meal”, which is detailed in the manual, so it also needs to be on hand. The recommended “standard meal” is included in the user manual: a nutritional drink and a cereal bar; all nutritional values are provided, so you can match them if the specific brands are not easily available in your area\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cp>\u003Cstrong>After the test:\u003C\u002Fstrong>\u003C\u002Fp>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Make sure the test results are uploaded to the Alimetry server. It happens automatically and will also be shown in the app\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Ch3 class=\"wp-block-heading\">What will the test deliver?\u003C\u002Fh3>\n\n\n\n\u003Cp>The test aims to detect the causes of overlapping gastric symptoms with distinct underlying phenotypes. \u003Ca href=\"https:\u002F\u002Fwww.science.org\u002Fdoi\u002F10.1126\u002Fscitranslmed.abq3544\">In this study\u003C\u002Fa>, researchers tested 43 patients with indistinguishable symptoms and were able to identify two distinct subgroups. \u003C\u002Fp>\n\n\n\n\u003Cp>The Gastric Alimetry platform is currently being used in clinical practice to differentiate between chronic nausea and vomiting syndromes (NVSs) that originate in the gut and those that arise through a centrally mediated pathway—a phenotype often tied to anxiety and depression.\u003C\u002Fp>\n\n\n\n\u003Cp>The 64-channel reading of the Alimetry devices focuses on the fact that gastric dysfunctions are associated with abnormalities in the gastric bioelectrical slow waves. As shown \u003Ca href=\"https:\u002F\u002Fjournals.physiology.org\u002Fdoi\u002Fabs\u002F10.1152\u002Fajpgi.00049.2022\">in this study\u003C\u002Fa>, the device was efficient in differentiating between patients having gastric neuromuscular disease or dysregulation of the brain-gut interaction. \u003C\u002Fp>\n\n\n\n\u003Cp>At the moment it seems Alimetry is a good tool to detect the underlying causes of chronic NVS, and the company works on how to apply it to other gastrointestinal conditions, including functional dyspepsia and gastroparesis.\u003C\u002Fp>\n\n\n\n\u003Ch3 class=\"wp-block-heading\">The patient perspective from our editor-in-chief\u003C\u002Fh3>\n\n\n\n\u003Cp>I was excited to be the subject of this gastric sensor test. I am an average person, with a normal BMI, and no major gastric problems apart from a mild case of acidic reflux, which is easily managed by dietary choices.\u003C\u002Fp>\n\n\n\n\u003Cp>I don’t have noticeable symptoms in my everyday life, but this is the result of avoiding certain foods and beverages in excessive amounts and\u002For in the evening. Thus I was intrigued by what I will learn from the test.\u003C\u002Fp>\n\n\n\n\u003Cfigure class=\"wp-block-image size-large is-style-default\">\u003Cimg loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"524\" src=\"https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F12\u002Freport1-768x524.jpg\" alt=\"Gastric Alimetry Body Surface Gastric Sensor tmf\" class=\"wp-image-48313\" srcset=\"https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F12\u002Freport1-768x524.jpg 768w, https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F12\u002Freport1.jpg 836w\" sizes=\"auto, (max-width: 768px) 100vw, 768px\" \u002F>\u003Cfigcaption class=\"wp-element-caption\">From the Gastric Alimetry report\u003C\u002Ffigcaption>\u003C\u002Ffigure>\n\n\n\n\u003Cp>\u003Cstrong>Test preparation:\u003C\u002Fstrong>\u003C\u002Fp>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>I was told not to eat or drink anything for 6 hours preceding the test. This was scary. I don’t mind not eating, but I normally drink at least a few cups of water\u002Ftea during any 6-hours of my waking periods, so I tried drinking plenty of water just before the 6 hours started\u003C\u002Fli>\n\n\n\n\u003Cli>Nevertheless, by the time I was ready to go, I was very thirsty. Going for a 10+ kilometers walk during the 6-hour fasting period was maybe a dumb idea\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cp>\u003Cstrong>Test process: \u003C\u002Fstrong>\u003C\u002Fp>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>I am short, and the array placement was surely out of the average, it ended way below my belly button. It was also noted in the final report. Nevertheless, the results were valid.\u003C\u002Fli>\n\n\n\n\u003Cli>The test process was a breeze, after the initial measurements were taken, I took a comfortable – reclining – position, connected my laptop to the big screen in front of me and started binge-watching.\u003C\u002Fli>\n\n\n\n\u003Cli>I was told not to move a lot, not to talk a lot and not to laugh – if possible. Watching Taskmaster was slightly jeopardising the latter, I don’t recommend this show for gastric alimetry.\u003C\u002Fli>\n\n\n\n\u003Cli>The first 30 minutes were the baseline readings, still with an empty stomach. Then I had 10 minutes to consume a test meal: a small drink and a large cereal bar.\u003C\u002Fli>\n\n\n\n\u003Cli>Following the meal came 4 hours of the actual test. It was nothing demanding, the app chimed every time when it was time to update my symptoms and warned me when I was making “excessive movements”.\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cfigure class=\"wp-block-image size-large is-style-default\">\u003Cimg loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"479\" src=\"https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F12\u002Freport3-768x479.jpg\" alt=\"Gastric Alimetry Body Surface Gastric Sensor tmf\" class=\"wp-image-48311\" srcset=\"https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F12\u002Freport3-768x479.jpg 768w, https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F12\u002Freport3.jpg 829w\" sizes=\"auto, (max-width: 768px) 100vw, 768px\" \u002F>\u003Cfigcaption class=\"wp-element-caption\">Very obvious activity after the meal, artifacts mean my  detected movements\u003C\u002Ffigcaption>\u003C\u002Ffigure>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>I’m not sure if that was the result of not drinking anything – apart from the 200 ml nutritional drink – for 10 hours and 40 minutes, but I experienced the worst reflux episode I had for years during the test. The symptoms almost immediately ceased after I downed a litre of water at the completion. However, I figured that provoking symptoms during the test was probably the whole point.\u003C\u002Fli>\n\n\n\n\u003Cli>I found one thing confusing though. You need to evaluate your symptoms on a scale between 0 (non-existent) and 10 (most severe imaginable) during the test in several areas like upper gut pain, nausea, heartburn or stomach burn and some more. I was not sure how to score my discomfort. I have a vivid imagination, so I would not dare to rate the worst contractions I had during labor as 10. There can be easily more pain in the world, I just never experienced it. Thus I never rated my symptoms above  3. But this might be all right as well, as I was in no big pain.\u003C\u002Fli>\n\n\n\n\u003Cli>The results were comforting, my report came back normal, noting that my symptoms don’t seem to correlate with the meal and fall within a sub-clinical range. This reinforced my previous guess that they were simply the result of not drinking anything for an extended period.\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Ch3 class=\"wp-block-heading\">Conclusion\u003C\u002Fh3>\n\n\n\n\u003Cp>The Gastric Alimetry device is a first-of-a-kind solution, fully fitting all principles of digital health. It is making patients the point of care and it targets a niche area with massive demand. I am eager to see where Body Surface Gastric Mapping develops in the coming years.\u003C\u002Fp>\n\n\n\n\u003Cp>The total time requirement of such a test is significant, patients need to dedicate a total of 10.5 hours to it. The discomfort of the prolonged process is tolerable, many gastric diagnostic methods are much more demanding. If you have chronic NVS and would like to find a way to detect its causes, it is well worth the effort. \u003C\u002Fp>\n",false,{"rendered":22,"protected":20},"\u003Cp>There is a huge demand for a better understanding of the workings of our gastric systems, and so far nobody could meaningfully collect digital health data about it. I was eager to review Alimetry’s Body Surface Gastric Mapping system\u003C\u002Fp>\n",6,48321,"closed",true,"","standard",{"_acf_changed":20,"footnotes":27},[31],496,[33,34,35,36,37,38,39],7715,623,7717,7707,7709,7711,7713,[],[],[43,44,45,46,47],1597,1617,2079,2139,3025,[49,14,50,51,52,53,54,55,56,57,58,59,60,61,62],"post-48309","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-sensors-trackers","tag-gut-sensor","tag-review","tag-stomach-sensor","tag-gastric-alimetry","tag-gastric-sencor","tag-body-surface-gastric-mapping","tag-alimetry",{"id":24,"alt_text":64,"caption":27,"description":27,"media_type":65,"media_details":66,"post":5,"source_url":99},"Gastric Alimetry Body Surface Gastric Mapping TMF sensor patient doctor hospital","image",{"width":67,"height":68,"file":69,"filesize":70,"sizes":71,"image_meta":97},1800,1012,"2022\u002F12\u002Ftmf_article_343-01.png",65996,{"medium":72,"large":79,"thumbnail":85,"medium_large":90,"1536x1536":91},{"file":73,"width":74,"height":75,"mime-type":76,"filesize":77,"source_url":78},"tmf_article_343-01-370x208.png","370","208","image\u002Fpng","29264","https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F12\u002Ftmf_article_343-01-370x208.png",{"file":80,"width":81,"height":82,"mime-type":76,"filesize":83,"source_url":84},"tmf_article_343-01-768x432.png","768","432","82454","https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F12\u002Ftmf_article_343-01-768x432.png",{"file":86,"width":87,"height":87,"mime-type":76,"filesize":88,"source_url":89},"tmf_article_343-01-150x150.png","150","14283","https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F12\u002Ftmf_article_343-01-150x150.png",{"file":80,"width":81,"height":82,"mime-type":76,"filesize":83,"source_url":84},{"file":92,"width":93,"height":94,"mime-type":76,"filesize":95,"source_url":96},"tmf_article_343-01-1536x864.png","1536","864","212841","https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F12\u002Ftmf_article_343-01-1536x864.png",{"aperture":98,"credit":27,"camera":27,"caption":27,"created_timestamp":98,"copyright":27,"focal_length":98,"iso":98,"shutter_speed":98,"title":27,"orientation":98},"0","https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F12\u002Ftmf_article_343-01.png",{"cta_type":101,"cta_color":27,"related_books":102,"related_posts_footer":106,"related_posts":20,"subtitle":27},"subscribe",[103,104,105],34151,47427,30419,[107,108,109],15397,47625,48099,{"yoast_wpseo_title":111,"yoast_wpseo_metadesc":112,"yoast_wpseo_canonical":15},"What's Happening In Your Stomach? - Gastric Alimetry Review","So far nobody could meaningfully collect digital health data about the gastric tract. I was eager to review Alimetry's Body Surface Gastric Mapping system",{"self":114,"collection":120,"about":123,"author":126,"replies":129,"version-history":132,"predecessor-version":136,"wp:featuredmedia":140,"wp:attachment":143,"wp:term":146,"curies":162},[115],{"href":116,"targetHints":117},"https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Fposts\u002F48309",{"allow":118},[119],"GET",[121],{"href":122},"https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Fposts",[124],{"href":125},"https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Ftypes\u002Fpost",[127],{"embeddable":26,"href":128},"https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Fusers\u002F6",[130],{"embeddable":26,"href":131},"https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Fcomments?post=48309",[133],{"count":134,"href":135},16,"https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Fposts\u002F48309\u002Frevisions",[137],{"id":138,"href":139},48407,"https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Fposts\u002F48309\u002Frevisions\u002F48407",[141],{"embeddable":26,"href":142},"https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Fmedia\u002F48321",[144],{"href":145},"https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Fmedia?parent=48309",[147,150,153,156,159],{"taxonomy":148,"embeddable":26,"href":149},"category","https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Fcategories?post=48309",{"taxonomy":151,"embeddable":26,"href":152},"post_tag","https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Ftags?post=48309",{"taxonomy":154,"embeddable":26,"href":155},"project_category","https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Fproject_category?post=48309",{"taxonomy":157,"embeddable":26,"href":158},"contact_email_category","https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Fcontact_email_category?post=48309",{"taxonomy":160,"embeddable":26,"href":161},"yst_prominent_words","https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Fyst_prominent_words?post=48309",[163],{"name":164,"href":165,"templated":26},"wp","https:\u002F\u002Fapi.w.org\u002F{rel}",[167],{"id":109,"date":168,"date_gmt":169,"guid":170,"modified":172,"modified_gmt":173,"slug":174,"status":13,"type":14,"link":175,"title":176,"content":178,"excerpt":180,"author":23,"featured_media":182,"comment_status":25,"ping_status":25,"sticky":26,"template":27,"format":28,"meta":183,"categories":184,"tags":187,"project_category":195,"contact_email_category":198,"yst_prominent_words":199,"class_list":208,"better_featured_image":221,"acf":240,"yoast_meta":252,"_links":255},"2022-11-24T10:00:00","2022-11-24T09:00:00",{"rendered":171},"https:\u002F\u002Fmedicalfuturist.com\u002F?post_id=48099&_wpnonce=91e96b224b&status=auto-draft&type=post","2024-01-11T18:04:26","2024-01-11T17:04:26","gene-pathway-analysis-in-action-3x4-dna-test-review","https:\u002F\u002Fmedicalfuturist.com\u002Fgene-pathway-analysis-in-action-3x4-dna-test-review",{"rendered":177},"Gene Pathway Analysis In Action – 3×4 DNA Test Review",{"rendered":179,"protected":20},"\n\u003Cp>In the past couple of years, I have taken at least 10 genetic tests, including this latest DNA test from\u003Ca href=\"https:\u002F\u002Fwww.3x4genetics.com\u002F\"> 3×4 Genetics\u003C\u002Fa>. This may seem excessive, but I have my reasons. I graduated from medical school as a genetic specialist and completed my PhD as a clinical genomics researcher, and although I turned to medical futurism, my original field never ceases to fascinate me. I’m very curious about how these tests advance and hope I might be able to provide insights for patients worldwide about what they can expect to learn from such tests and what those tests can really deliver.\u003C\u002Fp>\n\n\n\n\u003Cp>Thus, I didn’t hesitate for a second to get yet another test and try the pathway analysis 3×4 Genetics offers. \u003C\u002Fp>\n\n\n\n\u003Cfigure class=\"wp-block-image size-large is-resized is-style-default\">\u003Cimg decoding=\"async\" src=\"https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F11\u002FTMF-disclaimer-1-768x106.jpg\" alt=\"\" class=\"wp-image-48109\" width=\"800\" srcset=\"https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F11\u002FTMF-disclaimer-1-768x106.jpg 768w, https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F11\u002FTMF-disclaimer-1.jpg 991w\" sizes=\"(max-width: 768px) 100vw, 768px\" \u002F>\u003C\u002Ffigure>\n\n\n\n\u003Ch3 class=\"wp-block-heading\">What is a pathway analysis?\u003C\u002Fh3>\n\n\n\n\u003Cp>“Traditional’ DNA tests typically offer you percentage values of disease risks, saying things like “you have 34% diabetes risk”. Even if that is an accurate estimate, it’s challenging to figure out what to do with that number, especially if the test provider’s control population may significantly differ from yours. In my case, living in the middle of Europe, such values would tell more if they were compared to the Caucasian population in Central Europe – which they are not. Therefore while you receive quantified results, it’s really hard to use those results in your health or disease management\u003C\u002Fp>\n\n\n\n\u003Cp>Pathway analysis tries a different approach, focusing not on single genes, but on the “functions” of those genes. \u003Ca href=\"https:\u002F\u002Fwww.frontiersin.org\u002Farticles\u002F10.3389\u002Ffphys.2015.00383\u002Ffull\">Pathway Analysis\u003C\u002Fa> (PA) aims to detect relevant groups of related genes and seeks to overcome the problem of interpreting overwhelmingly large lists of important but isolated genes detached from context. \u003C\u002Fp>\n\n\n\n\u003Cp>In plain English, PA aims to analyse the ways our bodies work and find the ones in which we may have problems. \u003C\u002Fp>\n\n\n\n\u003Ch3 class=\"wp-block-heading\">How to do the DNA test\u003C\u002Fh3>\n\n\n\n\u003Cp>The 3×4 test didn’t differ significantly from other tests. You collect your sample with a cheek swab and send the package back to the company. It then will be analysed in a lab, and you get the results in about a month.\u003C\u002Fp>\n\n\n\n\u003Cfigure class=\"wp-block-image size-full is-style-default\">\u003Cimg loading=\"lazy\" decoding=\"async\" width=\"756\" height=\"408\" src=\"https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F11\u002FBerci-3x4DNA-3.jpg\" alt=\"DNA test results 3x4 Genetics\" class=\"wp-image-48103\"\u002F>\u003C\u002Ffigure>\n\n\n\n\u003Cp>During this time you are asked to fill out a questionnaire that provides some background info. It includes your basic metrics, like age and weight, lifestyle questions about how you eat and how much you exercise, and some basic questions about your general health and mood, among others. \u003C\u002Fp>\n\n\n\n\u003Ch3 class=\"wp-block-heading\">The report on 36 pathways\u003C\u002Fh3>\n\n\n\n\u003Cp>3×4 Genetics was the first provider offering to send the final report in an encrypted mail, which I think is a big plus. The report evaluated my results in 36 pathways. These come from 6 \u003Cstrong>main categories\u003C\u002Fstrong> (and several sub-categories):\u003C\u002Fp>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>\u003Cstrong>Cellular \u003C\u002Fstrong>(Methylation, Inflammation, Oxidative stress, Detoxification)\u003C\u002Fli>\n\n\n\n\u003Cli>\u003Cstrong>Systems \u003C\u002Fstrong>(Mood & behavior, Collagen & joints, Bone health, Glucose & insulin, Memory & brain health, Histamine overload, Hormone balance)\u003C\u002Fli>\n\n\n\n\u003Cli>\u003Cstrong>Cardiovascular health\u003C\u002Fstrong> (Vascular health, Cholesterol, Blood clotting, Blood pressure)\u003C\u002Fli>\n\n\n\n\u003Cli>\u003Cstrong>Energy\u003C\u002Fstrong> (Adipogenesis, Weight gain & weight loss resistance, Exercise response, Pro-inflammatory fat, Energy expenditure, Appetite\u002FSatiety\u002FIntake)\u003C\u002Fli>\n\n\n\n\u003Cli>\u003Cstrong>Activity\u003C\u002Fstrong> (Power, Injury, Recovery, Training response, Endurance)\u003C\u002Fli>\n\n\n\n\u003Cli>\u003Cstrong>Nutritients\u003C\u002Fstrong> (Caffeine, Choline, Folate, Vitamin B12, Vitamin D, Fatty acids, Gluten, Vitamin C, Salt, Iron overload)\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cp>The workings of my 36 pathways were evaluated on a 4-grade scale (low-medium-high-very high), showing how close\u002Ffar I am from the optimal, with low being the closest to the ideal. \u003C\u002Fp>\n\n\n\n\u003Ch3 class=\"wp-block-heading\">The counselling was excellent\u003C\u002Fh3>\n\n\n\n\u003Cp>The follow-up counselling session is a crucial part of all genetic tests, I would never suggest anyone take a DNA test without professional support to analyse the results. \u003C\u002Fp>\n\n\n\n\u003Cfigure class=\"wp-block-image size-full is-style-default\">\u003Cimg loading=\"lazy\" decoding=\"async\" width=\"751\" height=\"467\" src=\"https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F11\u002FBerci-3x4DNA-2.jpg\" alt=\"\" class=\"wp-image-48105\"\u002F>\u003C\u002Ffigure>\n\n\n\n\u003Cp>This was by far the most useful counselling session I’ve ever had, offering methods, dietary and supplements advice to counter my problematic tendencies. I learned, for example, how not paying attention to proper resting can turn into anxiety, or how foods high in histamine might affect my psychological well-being. \u003C\u002Fp>\n\n\n\n\u003Ch3 class=\"wp-block-heading\">I did learn some new things, and they make sense\u003C\u002Fh3>\n\n\n\n\u003Cp>The report contained lots of things I was already aware of from my previous genetic tests, but it also offered some interesting new inputs. \u003C\u002Fp>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>It highlighted that I’m “highly resistant in releasing fat from stores”, which is in line with my extended family being unanimously obese. Without very carefully managing my weight, I would be overweight too. Fortunately, my lifestyle has kept my BMI under 23 for my entire life and I plan to keep on doing so.\u003C\u002Fli>\n\n\n\n\u003Cli>The report also explained why I was always good in sprint runs and terrible in long-distance runs: I am on the lower end of the endurance scale. On the other hand, I do particularly well in power sports. I also learned that I recover from exercises somewhat slowly, and need to support the process in several different ways.\u003C\u002Fli>\n\n\n\n\u003Cli>“As a slow metabolizer,” I also need to limit my caffeine intake – another insight that reinforces what I learned by experience. Drinking coffee after 3 pm will make me sleep unwell. Now I can be sure I’m not just imagining it. \u003C\u002Fli>\n\n\n\n\u003Cli>I also scored “very high” on the mood&balance scale, meaning I may be highly susceptible to an imbalance (anxiety, depression and related behaviours). As someone with a dopamine reuptake disorder, this also makes a lot of sense and explains my novelty-seeking nature, and why I constantly need to get into something new, like chess and baseball and so on. The counsellor also explained how important it is for me to find balance, to make sure my adventure-seeking would not cause anxiety.\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Ch3 class=\"wp-block-heading\">Pros and cons\u003C\u002Fh3>\n\n\n\n\u003Cp>All in all, I was happy with the process and the results, the company provided great customer support, although I think it would be impossible to properly interpret the report without the counselling session.\u003C\u002Fp>\n\n\n\n\u003Cp>\u003Cstrong>Pros\u003C\u002Fstrong>:\u003C\u002Fp>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>focus on genetic pathways\u003C\u002Fli>\n\n\n\n\u003Cli>excellent counselling session\u003C\u002Fli>\n\n\n\n\u003Cli>strong privacy measures\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cp>\u003Cstrong>Cons\u003C\u002Fstrong>:\u003C\u002Fp>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>it was challenging to interpret the results without genetic counselling\u003C\u002Fli>\n\n\n\n\u003Cli>no online dashboard for the report, just a static PDF\u003C\u002Fli>\n\u003C\u002Ful>\n",{"rendered":181,"protected":20},"\u003Cp>I tried the pathway analysis DNA test by 3×4 Genetics. This method offers a lot if you are looking for results you can actually use in health\u002Fdisease management. \u003C\u002Fp>\n",48159,{"_acf_changed":20,"footnotes":27},[185,186],488,489,[34,188,189,190,191,192,193,194],7693,7695,7697,7699,213,258,259,[196,197],950,951,[],[200,201,202,203,204,47,205,206,207],5469,1571,1969,1973,1981,3281,3877,4705,[209,14,50,51,52,53,54,210,211,57,212,213,214,215,216,217,218,219,220],"post-48099","category-genomics","category-personalized-medicine","tag-dna-test","tag-dna-test-review","tag-3x4-genetics","tag-pathway-analysis","tag-dna-testing","tag-genetic-test","tag-genetic-testing","project_category-medical-professionals","project_category-patients",{"id":182,"alt_text":222,"caption":27,"description":27,"media_type":65,"media_details":223,"post":109,"source_url":239},"Genetic test DNA test, genes",{"width":224,"height":225,"file":226,"sizes":227,"image_meta":238},1280,720,"2022\u002F11\u002F3x4Genetics_2.png",{"medium":228,"large":231,"thumbnail":234,"medium_large":237},{"file":229,"width":74,"height":75,"mime-type":76,"source_url":230},"3x4Genetics_2-370x208.png","https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F11\u002F3x4Genetics_2-370x208.png",{"file":232,"width":81,"height":82,"mime-type":76,"source_url":233},"3x4Genetics_2-768x432.png","https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F11\u002F3x4Genetics_2-768x432.png",{"file":235,"width":87,"height":87,"mime-type":76,"source_url":236},"3x4Genetics_2-150x150.png","https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F11\u002F3x4Genetics_2-150x150.png",{"file":232,"width":81,"height":82,"mime-type":76,"source_url":233},{"aperture":98,"credit":27,"camera":27,"caption":27,"created_timestamp":98,"copyright":27,"focal_length":98,"iso":98,"shutter_speed":98,"title":27,"orientation":98},"https:\u002F\u002Fcdn.medicalfuturist.com\u002Fwp-content\u002Fuploads\u002F2022\u002F11\u002F3x4Genetics_2.png",{"cta_type":101,"cta_color":27,"related_books":241,"related_posts_footer":243,"related_posts":20,"subtitle":27,"key_takeaways":247},[242,105,104],24762,[244,245,246],34955,15120,14029,[248,250],{"title":249},"\u003Cp>The 3×4 Genetics DNA test offers a unique pathway analysis approach, focusing on gene functions rather than just disease risk percentages, providing more actionable insights for health and disease management\u003C\u002Fp>\n",{"title":251},"\u003Cp>The follow-up counseling session is essential for interpreting the complex results effectively, underscoring the importance of professional guidance in understanding and applying genetic test insights to personal health and lifestyle choices\u003C\u002Fp>\n",{"yoast_wpseo_title":253,"yoast_wpseo_metadesc":254,"yoast_wpseo_canonical":175},"Gene Pathway Analysis In Action - 3x4 DNA Test Review","I tried the pathway analysis DNA test by 3x4 Genetics. This method offers a lot if you are looking for results you can actually use in health management.",{"self":256,"collection":261,"about":263,"author":265,"replies":267,"version-history":270,"predecessor-version":274,"wp:featuredmedia":278,"wp:attachment":281,"wp:term":284,"curies":295},[257],{"href":258,"targetHints":259},"https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Fposts\u002F48099",{"allow":260},[119],[262],{"href":122},[264],{"href":125},[266],{"embeddable":26,"href":128},[268],{"embeddable":26,"href":269},"https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Fcomments?post=48099",[271],{"count":272,"href":273},12,"https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Fposts\u002F48099\u002Frevisions",[275],{"id":276,"href":277},54425,"https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Fposts\u002F48099\u002Frevisions\u002F54425",[279],{"embeddable":26,"href":280},"https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Fmedia\u002F48159",[282],{"href":283},"https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Fmedia?parent=48099",[285,287,289,291,293],{"taxonomy":148,"embeddable":26,"href":286},"https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Fcategories?post=48099",{"taxonomy":151,"embeddable":26,"href":288},"https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Ftags?post=48099",{"taxonomy":154,"embeddable":26,"href":290},"https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Fproject_category?post=48099",{"taxonomy":157,"embeddable":26,"href":292},"https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Fcontact_email_category?post=48099",{"taxonomy":160,"embeddable":26,"href":294},"https:\u002F\u002Fapi.medicalfuturist.com\u002Fwp-json\u002Fwp\u002Fv2\u002Fyst_prominent_words?post=48099",[296],{"name":164,"href":165,"templated":26},[298],{"id":105,"date":299,"date_gmt":300,"guid":301,"modified":303,"modified_gmt":304,"slug":305,"status":13,"type":306,"link":307,"title":308,"content":310,"excerpt":312,"author":23,"featured_media":314,"comment_status":25,"ping_status":25,"template":27,"yst_prominent_words":315,"class_list":318,"better_featured_image":321,"acf":341,"yoast_meta":363,"_links":366},"2020-10-01T10:54:54","2020-10-01T08:54:54",{"rendered":302},"https:\u002F\u002Fapi.medicalfuturist.com\u002F?post_type=book&p=30419","2023-03-12T18:16:29","2023-03-12T17:16:29","privacy-in-digital-health","book","https:\u002F\u002Fapi.medicalfuturist.com\u002Fbooks\u002Fprivacy-in-digital-health\u002F",{"rendered":309},"Hackers, Breaches and the Value of Health Data",{"rendered":311,"protected":20},"\n\u003Cp>Today, everyone needs to understand that there is no digital health without sacrificing a part of our privacy. The advanced technologies fueling the transformation cannot improve without our data; and without it, they can’t be implemented as part of regular medical care. And COVID-19 has only made things worse.\u003C\u002Fp>\n\n\n\n\u003Cp>In this e-Book, we defined the three cornerstones of privacy of every privacy discussion going forward: the traditional, the new and the future spheres that deal with your health data, and put forward recommendations on how you can start protecting yourself.\u003C\u002Fp>\n",{"rendered":313,"protected":20},"\u003Cp>Today, everyone needs to understand that there is no digital health without sacrificing a part of our privacy. 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