We have no idea what the rapid technological development, the so-called fourth industrial revolution will bring upon us in the next decades. There is only one certainty: we will need a new set of skills to find our place in the future.

Terrorism is and will always be out there as we do not live in a world depicted in the movie Minority Report where crimes can be prevented by foreseeing them. We cannot and we do not want to supervise people’s lives as that would be the death of privacy. Also, disruptive technologies not only enhance […]

Through the rise of personalized medicine, carrying out genome tests at home became feasible. With a PhD in genomics, I’m always curious and excited to try out novelties in my field. This time, Futura Genetics offered me a genetic test, and I was happy to give it a try.



Navigenics: What my genome tells me to do

A few months ago, Navigenics.com offered me to analyze my saliva sample and genome. I happily accepted the offer and was curious to see what they could tell me. After graduating from medical school, I will start PhD training in personalized genetics this September so I’m quite into this emerging field of medicine.

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I sent my saliva sample back to their laboratory this January and received the results in about 3-4 weeks.

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I clicked on View my results and saw what kind of risks I have for certain medical conditions such as glaucoma, heart disease, prostate cancer, Crohn’s disease or osteoarthritis (9 conditions all together).

When I check one medical condition, I see something like that:

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They tell me my risk compared to the whole population.

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And how that medical condition is affected by environmental and genetic factors.

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And if I’m interested in the particular single nucleotide polymorphism they analyzed, I can check the details.

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Pros:

  • The information this service provided me with was useful and I will change some things in my lifestyle.
  • I can talk with a genetic counselor to discuss the results of my genetic variations.
  • I can print the results and share it with my doctor through an understandable report that mentions the references on which they based my risk percentages.
  • They help me what I can do in order to lower my risks for specific conditions. They also let me know things that prevent multiple conditions on the Navigenics panels.
  • Each condition is covered in details (causes, symptoms, treatments, etc.). This information is powered by Mayo Clinic.
  • I can find support groups or more information on prevention.

Cons:

  • Let’s say 3 SNPs tell me I have elevated risk for heart disease. But next year, they will discover 4 new ones that defend me from this condition. So Navigenics, just like any other similar companies, can only tell me risk percentages that might change a lot in the future.
  • For example, if based on my genomic results, I have elevated risk for heart disease, what I can do to lower this risk? Exercises, healthy lifestyle, etc. Things you can tell me without analyzing my genome. Though it’s not the fault of the service, but of the state genetics is in at the moment.
  • It’s still way too expensive compared to what I get for my money as the results cannot really be used for medical decisions  (I got a free package so I know I shouldn’t say that).
  • Well, a few genetic tests can be useful when making medical decisions, but such tests should be ordered only by medical professionals. Or if not, at least genetic counseling should be for free as patients need serious guidance when reading the results of their genomic variations. (Update: Navigenics provides free genetic counseling for all Health Compass members and 1 hour of free counseling for all Insight members. And you can order the tests through a medical professional or on your own.)
  • I think I can handle many things but it was almost impossible for me to understand which documents I have to send back to the lab with my saliva sample. A step-by-step video tutorial would be useful.

I’m thankful to the Team of Navigenics.com for showing me how their service works in action. I’m impressed and looking forward to seeing how they can make their service even better.

2009 Predictions in Personalized Genetics

Hsien-Hsien Lei shared her 2009 predictions about personalized genetics with us and that’s where I would like to leave a few comments.

1. 23andMe will begin selling their tests on drugstore shelves.

I think they would be sued soon.

2. President Barack Obama will be offered genome sequencing.

He cannot and mustn’t accept it.

3. Apple will launch iSEQ – instant DNA testing and analysis in a handheld device.

I don’t think Apple will ever enter this market.

4. The first 10 participants in the Personal Genome Project will band together to be called Fantastic Ten. Each will reveal secret superpowers that are embedded in their DNA.

That is a possibility. But if they think wisely, they will never do something like that.

5. The U.S. government passes laws to obtain DNA from all its citizens which it says will help protect the innocent and punish criminals.

It was only possible in Iceland and will never be possible in the US.

What I think about 2009 is that Navigenics will rule the market even if its service is more expensive than the kit of 23andMe.

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Further reading:

AccessDNA: Know Your Genetics

I’ve recently discovered AccessDNA on Twitter and I thought I should give it a try. On the main page, it says I should create my personalized report. Well, let’s do so.

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It asked me about the medical conditions that occurred in my family; environmental factors I have to face; tests I would be interested in, etc. And then I received the personalized genetic report; actually a list of genetic tests that might be useful for me.

accessdna-report

What can I do with that information? Yes, of course I want full genome scanning. But should this be my decision? Not the decision of my doctor? Just beacuse I reported to be of Caucasian descent, I should order genetic tests that cost several thousands of dollars?

You know what? I would love to hear the opinion of Steve Murphy here. And yours!