A collegue of mine pointed out that there is a journal for negative results in biomedical research,the Journal of Negative Results in BioMedicine:
Journal of Negative Results in BioMedicine is ready to receive manuscripts on all aspects of unexpected, controversial, provocative and/or negative results/conclusions in the context of current tenets, providing scientists and physicians with responsible and balanced information to support informed experimental and clinical decisions.
Not every unexpected observation, controversial conclusion or proposed model will turn out to be of such groundbreaking significance. Nor will they even be confirmed by subsequent scientific progress. However, we strongly believe that such “negative” observations and conclusions, based on rigorous experimentation and thorough documentation, ought to be published in order to be discussed, confirmed or refuted by others. In addition, publishing well documented failures may reveal fundamental flaws and obstacles in commonly used methods, drugs or reagents such as antibodies or cell lines, ultimately leading to improvements in experimental designs and clinical decisions.
Certainly, there was a niche for that and I’m curious to see how it evolves.